Oktawiec Lab

    Publications

    Before Independent Career
    1. Oktawiec, J.†; Nadeem, H.†; Ebrahim, O. M.; Chen, Y.; Byrnes, J.; Thompson, M. P.; Shukla, D.; Gianneschi, N. C. “Altering Beta-Hairpin Folding within Peptide Brush Polymers.” Manuscript in progress. †Contributed equally.
    2. Wang, M.; Truica, M.; Gattis, B.; Oktawiec, J.; Sagar, V.; Basu, A.; Bertin, P.; Zhang, X.; Abdulkadir, S.; Gianneschi, N. C. “Heterobifunctional proteomimetic polymers for targeted protein degradation.” Nat. Commun. 2025 Just accepted.
    3. Richardson-Matthews, R.; Velko, K.; Bhunia, B.; Ghosh, S.; Oktawiec, J.; Brunzelle, J. S.; Dang, V. T.; Nguyen, A. I. “Metal-α-Helix Peptide Frameworks.” J. Am. Chem. Soc. 2025, 147, 17433-17447.
    4. Chen, Y.; Zilberzwige-Tal, S.; Rosenmann, N. D.; Oktawiec, J.; Nensel, A. K.; Ma, Q.; Lichtenstein, S.; Gazit, E.; Gianneschi, N. C. “Bottom-Up Construction of Hierarchically Porous Nanostructures via Peptide-Coordination Assembly.” Matter, 2025, doi:10.1016/j.matt.2025.102108.  
    5. Oktawiec, J.; Ebrahim, O. M.; Chen, Y.; Su, K.; Sharpe, C.; Rosenmann, N. D.; Barbut, C.; Weigand, S.; Byrnes, J.; Thompson, M. P.; Qiao, B.; Gianneschi, N. C. “Conformational Modulation and Polymerization-Induced Folding of Proteomimetic Peptide Brush Polymers.” Chem. Sci. 2024, 15, 13899.
    6. Heinz-Kunert, S. L.; Pandya, A.; Dang, V. T.; Oktawiec, J.; Nguyen, A. I. “Pore Restructuring of Peptide Frameworks by Mutations at Distal Packing Residues.” Biomacromolecules 2024, 25, 3, 2016.
    7. Halder, A.; Bain, D.; Pitt, T.; Shi, Z.; Oktawiec, J.; Lee, J.-H.; Tsangari, S.; Ng, M.; Fuentes-Rivera, J.; Forse, A.; Runcevski, T.; Muller, D.; Musser, A.; Milner, P. “Kinetic Trapping of Photoluminescent Frameworks During High-Concentration Synthesis of Non-Emissive Metal–Organic Frameworks.” Chem. Mater. 2023, 35, 10086.
    8. Hou, K.; Börgel, J.; Jiang, H. Z. H.; Adamji, H.; Zhuang, H.; Zhu, R.; Pantazis, D.; Kwon, H.; Rohde, R.; Chakarawet, K.; SantaLucia, D. J.; Dun, C.; Paley, M. V.; Turkiewicz, A. B.; Park, J. G.; Mao, H.; Taylor, J.; Zhu, Z.; Alp, E. E.; Zhao, J.; Hu, M.; Lavina, B.; Lv, Xudong,; Oktawiec, J.; Colombo, V.; Grandjean, F.; Long, G. J.; Bill, E.; Britt, R. D.; Urban, J. J.; Reimer, J. A.; Neese, F.; Román-Leshkov, Y.; Long, J. R. “Generation of high-spin Fe(IV)-oxo species through dioxygen activation in metal–organic frameworks.” Science 2023, 382, 547.
    9. Hess, S.; Coppola, F.; Dang, V. T.; Tran, P. N.; Mickel, P.; Oktawiec, J.; Ren, Z.; Král, P.; Nguyen, A. “Noncovalent peptide assembly enables crystalline, permutable, and reactive thiol frameworks.” J. Am. Chem. Soc. 2023, 145, 19588.  
    10. Zhu, Z.; Parker, S. T.; Forse, A. C.; Lee, J.-H.; Siegelman, R. L.; Milner, P. J.; Tsai, H.; Ye, M.; Paley, M.; Uliana, A. A.; Oktawiec, J.; Dinakar, B.; Didas, S. A.; Reimer, J. A.; Neaton, J. B.; Long, J. R. “Diamine−Appended Olsalazine-Based Metal−Organic Frameworks for Cooperative CO2 Capture.” J. Am. Chem. Soc. 2023, 145, 17151.    
    11. Halder, A.; Bain, D. C.; Oktawiec, J.; Addicoat, M. A.; Tsangari, S.; Fuentes-Rivera, J. J.; Pitt, T. A.; Musser, A. J.; Milner, P. J. “Enhancing Dynamic Spectral Diffusion in Metal–Organic Frameworks through Defect Engineering.” J. Am. Chem. Soc. 2023, 145, 1072.
    12. Berger, O.; Battistella, C.; Chen, Y.; Oktawiec, J.; Siwicka, Z. E.; Tullman-Ercek, D.; Wang, M.; Gianneschi, N. C. “A Mussel Adhesive-Inspired Proteomimetic Polymer.” J. Am. Chem. Soc. 2022, 144, 4383.  
    13. Oktawiec, J.; Jiang, H. Z. H.; Turkiewicz, A. B.; Long, J. R. “Influence of the primary and secondary coordination spheres on nitric oxide adsorption and reactivity in cobalt(II)–triazolate frameworks.” Chem. Sci. 2021, 12, 14590.
    14. Sun, H.; Qiao, B.; Choi, W.; Hampu, N.; Collins-McCallum, N.; Thompson, M.; Oktawiec, J.; Weigand, S.; Ebrahim, O.; Olvera de la Cruz, M.; Gianneschi, N. C. “On the Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics.” ACS Cent. Sci. 2021, 7, 2063.  
    15. Zhou, X.; Gong, X.; Cao, W.; Forman, C. J.; Oktawiec, J.; D’Alba, L.; Sun, H.; Thompson, M. P.; Hu, Z.; Kapoor, U.; McCallum, N. C.; Malliakas, C. D.; Farha, O. K.; Jayaraman, A.; Shawkey M. D.; Gianneschi, N. C. “Anisotropic Synthetic Allomelanin Materials via Solid State Polymerization of Self‐Assembled 1, 8‐Dihydroxynaphthalene Dimers.” Angew. Chem. Int. Ed. 2021, 60,17464.
    16. Samkian, A. E.; Kiel, G. R.; Jones, C. G.; Bergman, M. H.; Oktawiec, J.; LaVallo, V.; Nelson, H. M.; Tilley, T. D. “MicroED Elucidation of Diverse Solid-State Packing in a Class of Electron-Deficient Expanded Helicenes.”Angew. Chem. Int. Ed. 2021, 50, 2523.
    17. Oktawiec, J.; Jiang, H. Z. H.; Vitillo, J. G.; Reed, D. A.; Darago, L. E.; Trump, B. A.; Bernales, V.; Li, H.; Colwell, K. A.; Furukawa, H.; Brown, C. M.; Gagliardi, L.; Long, J. R. “Negative cooperativity upon hydrogen bond-stabilized O2 adsorption in a redox-active metal–organic framework.” Nat. Commun. 2020, 11, 3087.   
    18. Reed, D. A.; Xiao, D. J.; Jiang, H. Z. H.; Chakarawet, K.; Oktawiec, J.; Long, J. R. “Biomimetic O2 Adsorption in an Iron Metal–Organic Framework for Air Separation.” Chem. Sci. 2020, 11, 1698.
    19. Taylor, M. K.; Juhl, M.; Hadaf, B. G.; Hwang, D.; Velasquez, E.; Oktawiec, J.; Lefton, J. B.; Runcevski, T.; Long, J. R.; Lee, J.-W. “Palladium-Catalyzed Oxidative Homocoupling of Pyrazole Boronic Esters to Access Versatile Bipyrazoles and the Flexible Metal–Organic Framework Co(4,4′-bipyrazolate).” Chem. Commun. 2020, 56, 1195.
    20. Jeong, S.; Heo, T. W.; Oktawiec, J.; Shi, R.; Kang, S. Y.; White, J.; Schneeman, A.; Zaia, E.; Wan, L.; Ray, K.; Liu, Y.-S.; Stavila, V.; Guo, J.; Long, J. R.; Wood, B.; Urban, J. “A Mechanistic Analysis of Phase Evolution and Hydrogen Storage Behavior in Nanocrystalline Mg(BH4)2 within Reduced Graphene Oxide.” ACS Nano, 2020, 14, 1745.
    21. Jaramillo, D. E.; Reed, D. A.; Jiang, H. Z. H.; Oktawiec, J.; Mara, M. W.; Forse, A. C.; Lussier, D.; Murphy, R. A.; Cunningham, M.; Colombo, V.; Shuh, D. K.; Reimer, J. A.; Long, J. R. “Selective N2 Adsorption via Backbonding in a Metal–Organic Framework with Exposed Vanadium(II) Sites.” Nat. Mater. 2020,19, 517.
    22. Gonzalez, M. I.; Turkiewicz, A. B.; Darago, L. E.; Oktawiec, J.; Bustillo, K.; Grandjean, F.; Long, G. J.; Long, J. R. “Confinement of atomically-defined metal halide sheets in a metal–organic framework.” Nature 2020, 577, 64.
    23. Jeong, S.; Milner, P. J.; Wan, L. F.; Lu, Y.-S.; Oktawiec, J.; Zaia, E. W.; Guo, J.; Prendergast, D.; Long, J. R.; Urban, J. J. “Runaway carbon dioxide conversion leads to enhanced uptake in a nanohybrid form of porous magnesium borohydride.” Adv. Mater. 2019, 31, 1904252.
    24. Nguyen, A. I.; Van Allsburg, K. M.; Terban, M. W.; Bajdich, M.; Oktawiec, J.; Ziegler, M. S.; Dombrowski, J. P.; Lakshmi, K. V.; Drisdell, W.; Yano, J.; Billinge, S. J. L.; Tilley, T. D. “Stabilization of reactive Co4O4 cubane oxygen-evolution catalysts within porous frameworks.” Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 11630.
    25. Barnett, B. R.; Parker, S.; Paley, M. V.; Gonzalez, M. I.; Biggins, N.; Oktawiec, J.; Long, J. R. “Thermodynamic Separation of 1-Butene from 2-Butene in Metal–Organic Frameworks with Open Metal Sites.” J. Am. Chem. Soc, 2019, 141, 18325.
    26. Aubrey, M. L.; Kapelewski, M. T.; Melville, J. F.; Oktawiec, J.; Presti, D.; Gagliardi, L.; Long, J. R. “Chemiresistive Detection of Gaseous Hydrocarbons and Interrogation of Charge Transport in Cu[Ni(2,3-pyrazinedithiolate)2] by Gas Adsorption.” J. Am. Chem. Soc. 2019, 141, 5005.
    27. Forse, A. C.; Milner, P. J.; Lee, J.; Redfearn, H. N.; Oktawiec, J.; Siegelman, R. L.; Martell, J. D.; Dinakar, B.; Porter-Zasada, L. B.; Gonzalez, M. I.; Neaton, J. B.; Long, J. R.; Reimer, J. A. “Elucidating CO2 Chemisorption in Diamine-Appended Metal− Organic Frameworks.” J. Am. Chem. Soc. 2018, 140, 18016.
    28. McGuirk, C. M.; Siegelman, R. L.; Drisdell, W. S.; Runčevski, T.; Milner, P. J.; Oktawiec, J.; Wan, L. F.; Su, G. M.; Jiang, H. Z. H.; Reed, D. A.; Gonzalez, M. I.; Prendergast, D.; Long, J. R. “Cooperative Adsorption of Carbon Disulfide in Diamine-Appended Metal–Organic Frameworks.” Nat. Commun., 2018, 9, 5133.
    29. McGuirk, C. M.; Runčevski, T.; Oktawiec, J.; Turkiewicz, A.; Taylor, M. K.; Long, J. R. “Influence of Metal Substitution on the Pressure-Induced Phase Change in Flexible Zeolitic Imidazolate Frameworks.” J. Am. Chem. Soc. 2018, 140, 15924.
    30. Kapelewski, M. T.; Oktawiec, J.; Runčevski, T.; Gonzalez, M. I.; Long, J. R. “Separation of Xenon and Krypton in the Metal–Organic Frameworks M2(m-dobdc) (M=Co, Ni).” Isr. J. Chem. 2018, 58, 1138.
    31. Taylor, M. K.; Runčevski, T.; Oktawiec, J.; Bachman, J. E.; Siegelman, R. L.; Jiang, H. Z.; Mason, J. A.; Tarver, J. D.; Long, J. R. “Near-Perfect CO2/CH4 Selectivity Achieved through Reversible Guest Templating in the Flexible Metal–Organic Framework Co(bdp).”J. Am. Chem. Soc. 2018,140, 10324.
    32. Park, J. G.; Aubrey, M. L.; Oktawiec, J.; Chakarawet, K.; Darago, L. E.; Grandjean, F.; Long, G. J.; Long, J. R. “Charge Delocalization and Bulk Electronic Conductivity in the Mixed-Valence Metal–Organic Framework Fe(1,2,3-triazolate)2(BF4)x.” J. Am. Chem. Soc. 2018, 140, 8526.  
    33. Reed, D. A.†; Keitz, B. K. †; Oktawiec, J.; Mason, J. A.; Runcevski, T.; Xiao, D. J.; Darago, L. E.; Crocellà, V.; Bordiga, S.; Long, J. R. “A Spin Transition Mechanism for Cooperative Adsorption in Metal–Organic Frameworks.” Nature 2017, 550, 96. † Contributed equally.
    34. Martell, J. D.; Porter-Zasada, L. D.; Forse, A. C.; Siegelman, R. L.; Gonzalez, M. I.; Oktawiec, J.; Runčevski, T.; Xu, J.; Srebro-Hooper, M.; Milner, P. J.; Colwell, K. A.; Autschbach, J.; Reimer, J. A.; Long, J. R. “Enantioselective Recognition of Ammonium Carbamates in a Chiral Metal–Organic Framework.” J. Am. Chem. Soc. 2017, 139, 16000.
    35. Levine, D. J.; Gonzalez, M. I.; Legendre, C. M.; Runčevski, T.; Oktawiec, J.; Colwell, K. A.; Long, J. R. “Calcium Coordination Solids for pH-Triggered Release of Olsalazine.” Chem. Med. Chem.2017, 12, 1739.
    36. Gonzalez, M. I.; Oktawiec, J.; Long, J. R. “Ethylene Oligomerization in Metal–Organic Frameworks Bearing Nickel(II) 2,2′-Bipyridine Complexes.” Faraday Discuss. 2017, 201, 351.
    37. Taylor, M. K.; Runcevski, T.; Oktawiec, J.; Gonzalez, M. C.; Mason, J. A.; Ye, J.; Brown, C.; Long, J.R. “Tuning the Adsorption-Induced Phase Change in the Flexible Metal−Organic Framework Co(bdp).” J. Am. Chem. Soc. 2016, 138, 15019.
    38. Xiao, D.; Oktawiec, J.; Milner, P.; Long, J. R. “Pore Environment Effects on Catalytic Cyclohexane Oxidation in Expanded Fe2(dobdc) Analogues.” J. Am. Chem. Soc. 2016, 138, 14371.
    39. Levine, D.; Runcevski, T.; Kapelewski, M.; Keitz, B.; Oktawiec, J.; Reed, D.; Mason, J.; Jiang, H.; Colwell, K.; Legendre, C.; Fitzgerald, S.; Long, J. R. “Olsalazine-Based Metal−Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery.” J. Am. Chem. Soc. 2016, 138, 10143.
    40. Mason, J. A.; Oktawiec, J.; Taylor, M. K.; Hudson, M. R.; Rodriguez, J.; Bachman, J. E.; Gonzalez, M. I.; Cervellino, A.; Guagliardi, A.; Brown, C. M.; Llewellyn, P. L.; Masciocchi, N.; Long, J. R. “Methane Storage in Flexible Metal-Organic Frameworks with Intrinsic Thermal Management.” Nature 2015, 527, 357.
    41. Chatterjee, S., Sarkar, S., Oktawiec, J., Mao, Z., Niitsoo, O., Stark, R. E. “Isolation and Biophysical Study of Fruit Cuticles.” J. Vis. Exp. 2012, 61, e3529, doi:10.3791/3529.